Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis
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چکیده
منابع مشابه
Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by CD94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I proteins; however, no function for HLA-E has yet been described. We show that natural killer (NK) cells can recognize target cells expressing H...
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Human leukocyte antigen class I molecules expressed by tumor cells play a central role in the regulation of natural killer (NK) cell-mediated immune responses. The proteasome inhibitor bortezomib has demonstrated significant activity in multiple myeloma (MM). We hypothesized that treatment of MM with bortezomib results in the reduction of cell-surface expression of class I and thereby sensitize...
متن کامل182 COOPERATION OF HLA - DR + AND NATURAL KILLER CELLS Antibody Plus C - mediated Lysis
NK cells mediate spontaneous killing of tumor-derived cells, virus-infected cells, and certain normal cells (1, 2). This type of cytotoxicity does not require presensitization of the donor. For example, PBMC of individuals who are seronegative or seropositive for a given virus are equally able to lyse targets infected with that virus (3). Production of IFN by lymphocytes exposed to virusinfecte...
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We have previously described (1) the in vitro isolation of chemically transformed cell lines resistant (C type) and sensitive (I type) to rejection mechanisms operative in normal mice. The experiments reported here utilize these two classes of transformed fibroblastic cell lines (I and C type) along with the parental nontransformed cell line (N type) to analyze the resistance or sensitivity of ...
متن کاملEvidence for natural killer cell-mediated protection from metastasis formation in uveal melanoma patients.
PURPOSE In uveal melanoma, low human leukocyte antigen (HLA) class I expression on primary tumors is associated with a decreased risk of metastasis. Consequently, it has been suggested that natural killer (NK) cells, which detect decreased expression of HLA class I, are involved in the immune control of metastases. In this study, three novel lines of evidence were identified that support a role...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.12.6313